Alteration of Lipid Profile Between Subclinical Hypothyroidism and Well-Matched Controls: A Meta-Analysis
This study aimed to explore the changes in total
cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol
(LDL-c), and high-density lipoprotein cholesterol (HDL-c) between subclinical
hypothyroidism (SCH) and well-matched euthyroid (EU) groups. Multiple databases
were searched for publications before December 1, 2021, including
cross-sectional studies on the association between SCH and lipid profile matched
by age, gender, and BMI. Twenty-five articles with 3347 participants were
included for meta-analysis. The results showed that the TC, TG, and LDL-c levels
of the SCH groups were higher than the EU groups (TC, SMD=0.49,
95% CI 0.27, 0.71, p<0.001) (TG, SMD=0.43, 95%
CI 0.21, 0.64, p<0.05 ) (LDL-c, SMD=0.75, 95% CI 0.46,
1.03, p<0.001 ). The HDL-c levels of the SCH group were lower than the
control group (SMD=–0.53, 95% CI –0.81,
–0.25, p<0.05). SCH has a larger impact on LDL-c than the other
three indicators. After subgroup analyses, there was a larger impact on lipid
alteration in the subgroup of TSH>10 μIU/ml, especially
on LDL-c. This study found that SCH was associated with altered lipid profiles.
Appropriate clinical treatment may be needed to prevent dyslipidemia and related
diseases. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Ger...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Liu, Jinjin Chen, Yun Ren, Bingxuan He, Yanhong Li, Fan Wang, Lingbo Wan, Siyuan Liu, Lixiang Shen, Hongmei Tags: Original Article: Endocrine Care Source Type: research