Prenatal dexamethasone exposure impaired vascular reactivity in adult male offspring cerebral arteries

Cerebrovascular disease is one of the leading causes of death worldwide. Middle cerebral artery (MCA) is the largest and most complex of cerebral arteries. The prenatal period is a critical time for development, which largely determines lifelong health. Clinically, glucocorticoids (GCs) administration to accelerate preterm fetal lung maturation has become standard practice. Prenatal GCs administration increases cardiovascular risks in offspring, but little is known regarding the side effects on offspring MCA function.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research