Percutaneous Coronary Intervention vs Coronary Artery Bypass Graft Surgery for Left Main Disease in Patients With and Without Acute Coronary Syndromes: A Pooled Analysis of 4 Randomized Clinical Trials

CONCLUSION AND RELEVANCE: Among largely stable patients undergoing left main revascularization and with predominantly low to intermediate coronary anatomical complexity, those with ACS had higher rates of early death. Nonetheless, rates of all-cause mortality through 5 years were similar with PCI vs CABG in this high-risk subgroup. The relative advantages and disadvantages of PCI vs CABG in terms of early stroke and long-term spontaneous MI and repeat revascularization were consistent regardless of ACS status.TRIAL REGISTRATION: ClinicalTrials.gov Identifiers: NCT00114972, NCT00422968, NCT01496651, NCT01205776.PMID:37256598 | PMC:PMC10233454 | DOI:10.1001/jamacardio.2023.1177

Source: Atherosclerosis - May 31, 2023 Category: Cardiology Authors: Prakriti Gaba Evald H Christiansen Per H Nielsen Sabina A Murphy Patrick T O'Gara Peter K Smith Patrick W Serruys A Pieter Kappetein Seung-Jung Park Duk-Woo Park Gregg W Stone Joseph F Sabik Marc S Sabatine Niels R Holm Brian A Bergmark Source Type: research