Paraneoplastic or treatment-associated dermatomyositis: a diagnostic challenge

Dermatol Online J. 2023 Apr 15;29(2). doi: 10.5070/D329260768.ABSTRACTDermatomyositis (DM) is a systemic autoimmune disorder characterized by proximal myopathy and dermatological findings. Approximately 15-30% of DM cases emerge as a paraneoplastic syndrome caused by a concomitant malignancy. Although more rare, in cancer patients DM has also been reported as a possible result of toxicity of some antineoplastic agents, such as taxanes and monoclonal antibodies. Herein, we report a 35-year-old woman with metastatic breast cancer who presented with skin lesions after initiation of paclitaxel and anti-HER2 agents. Clinical, laboratory, and histological findings were consistent with the diagnosis of DM.PMID:37220284 | DOI:10.5070/D329260768

Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Miguel Esperanca-Martins Sara Damaso Nuno Carreira Barbara Pena Catarina Correia Marta Aguado-Lobo Pablo Espinosa-Lara Luis Soares-de-Almeida Leonor Abreu Ribeiro Luis Costa Source Type: research