Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress

Inflammation is an integral component of cardiovascular disease and is thought to contribute to cardiac dysfunction and heart failure. While ischemia-induced inflammation has been extensively studied in the heart, relatively less is known regarding cardiac inflammation during non-ischemic stress. Recent work has implicated a role for Yes-associated protein (YAP) in modulating inflammation in response to ischemic injury; however, whether YAP influences inflammation in the heart during non-ischemic stress is not described.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research