Efficacy and safety of surgical treatment for 1 –2 cm sized lower pole of renal stone: network meta-analysis of randomized control trials

AbstractThe management of medium-sized (1 –2 cm) lower poles renal stone has been a contentious topic for endourologists. There are limited evidences to answer the best management options for medium-sized lower pole renal stone. This network meta-analysis provided high-level evidences on efficacy and safety of profile of PCNL, Mini-PCNL, Ultra-PCNL, RIRS, Micro-PCNL, SWL for management of medium-sized lower pole renal stone. Systemic review and network meta-analysis (NMA) of randomized control trials was conducted. The PICOS (Population, Interventions, Comparison, Outcomes, and Study) approach was used to look for relevant studies. Searches were conducted at major electronic databases like Medline via PubMed, Embase, Google Scholar, SCOPUS, ScienceDirect, Cochrane library, Web of Science, and ClinicalTrials.gov to find relevant articles from the inception to April 19, 2023. Fourteen randomized control trials involving 2194 pa tients were among these studies that met the eligibility criteria. Pooled SFR was Mini-PNCL 98% (95% CI 96–99%), Ultara-PCNL 96% (95% CI 93–98%), RIRS 90% (95% CI 88–92%), PCNL 88% (95% CI 85–92%), Micro-PCNL 77% (61–88%) and SWL 69% (95% CI 65–74%). Mini-PCNL provided a statistically si gnificant higher SFR compared to RIRS (RR = 2.43 91.52; 3.89)), Micro-PCNL (RR = 3.19 (1.09; 9.38)), and SWL (RR = 6.17 (3.65; 10.44)), but there was no statistical significance with standard PCNL (RR = 1.06 (0.52; 2.16)) and Ultra-PCNL (RR...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research