Phenotypic and Endotypic Determinants of Atopic Dermatitis Severity from the ADRN Registry

CONCLUSION: In a diverse US AD population, severity was associated with a history of atopic disorders, skin and extracutaneous bacterial and viral infections (by history and physical examination), higher IgE, eosinophilia and allergen sensitization, atopic skin manifestations (i.e., excoriation, hyperlinear palms and ichthyosis), and atopic ocular features (i.e., blepharitis, conjunctivitis, and ectropion) as well as asthma findings (i.e., wheezing). Data from our prospective registry significantly advances our understanding of AD phenotypes and endotypes, which is critical to achieve optimal management.PMID:37182563 | DOI:10.1016/j.jaip.2023.04.052

Source: Herpes - May 14, 2023 Category: Infectious Diseases Authors: Eric L Simpson Anna De Benedetto Mark Boguniewicz Peck Y Ong Stephanie Lussier Miguel Villarreal Lynda C Schneider Amy S Paller Emma Guttman-Yassky Jon M Hanifin Jonathan M Spergel Kathleen C Barnes Gloria David Briahnna Austin Donald Y M Leung Lisa A Bec Source Type: research