Association Between Clozapine Plasma Concentrations and Treatment Response: A Systematic Review, Meta-analysis and Individual Participant Data Meta-analysis

ConclusionsOur work confirmed that, in contrast to clozapine doses, clozapine plasma concentrations were related to a favourable clinical response, with a mean difference between responders and non-responders of 117 ng/mL. A threshold for a treatment response of 407 ng/mL was determined, with a high discriminatory capacity,  and a sensitivity and specificity of 71% and 89.1%, respectively.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research