Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome

Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mut...

Source: Clinical Epigenetics - April 29, 2023 Category: Research Authors: Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho and Keith D. Robertson Tags: Research Source Type: research