Application of Biomimetic Nanoparticles Based on the Cell Membrane in Tumor Therapy

Curr Top Med Chem. 2023 Apr 27. doi: 10.2174/1568026623666230427114622. Online ahead of print.ABSTRACTDue to their unique biological functionality, nanocarriers can be designed to deliver various anti-tumor drugs in vivo, which has a wide and important application prospect in the field of tumor therapy. However, poor biosafety, short blood circulation time, and weak targeting ability still limit the application of nanoparticles in tumor therapy. In recent years, with the development of biomedicine, the biomimetic technology-based biomembrane-mediated drug delivery system is expected to achieve a breakthrough in tumor-targeted therapy due to low immunogenicity, tumor targeting, the adjustability and versatility of intelligent nanocarrier design. This paper mainly reviews the research process of different types of the cell membrane (erythrocyte membrane, cancer cell membrane, bacterial membrane, stem cell membrane, and hybrid membrane)-camouflaged nanoparticles in tumor therapy, as well as the challenges and development prospects in clinical application.PMID:37102484 | DOI:10.2174/1568026623666230427114622
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research