Glypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular carcinoma

Conclusions89Zr- αGPC3 avidly accumulated in GPC3+ tumors with minimal off-target sequestration.89Zr- αGPC3 immuno-PET yielded a sensitivity of 100% and detected sub-millimeter tumors. This technology may improve diagnostic sensitivity of small HCC and select GPC3+ tumors for targeted therapy. Human trials are warranted to assess its impact.
Source: EJNMMI Research - Category: Radiology Source Type: research