Loading Intracranial Drug-Eluting Reservoirs Across the Blood –Brain Barrier With Focused Ultrasound

Efficient, sustained and long-term delivery of therapeutics to the brain remains an important challenge to treatment of diseases such as brain cancer, stroke and neurodegenerative disease. Focused ultrasound can assist movement of drugs into the brain, but frequent and long-term use has remained impractical. Single-use intracranial drug-eluting depots show promise but are limited for the treatment of chronic diseases as they cannot be refilled non-invasively. Refillable drug-eluting depots could serve as a long-term solution, but refilling is hindered by the blood –brain barrier (BBB), which prevents drug refills from accessing the brain.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Technical Note Source Type: research