Molecular Arms Races Shape the Evolution and Function of Antiviral Proteins

The Malik lab studies the causes and consequences of genetic conflicts that take place between different genomes (e.g., host-virus interactions, mitochondrial conflicts with nuclear genomes) or between components of the same genome (e.g., chromosomal competition at centromeric regions). We are interested in understanding these " molecular arms races " and how they drive recurrent genetic innovation, from the perspective of both evolutionary biology and human disease. Malik and his colleagues have used an evolutionary lens to dissect and discover both primate antiviral as well as viral adaptation strategies. This lecture will describe how we use evolution-guided mutagenesis approaches to dissect and enhance the function of antiviral proteins.For more information go tohttps://oir.nih.gov/walsAir date: 6/21/2023 2:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video