Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

This article summarizes relevant research and provides new microbiome-related strategies for exploring the mechanisms and treating patients with SLE.Recent FindingsSLE patients have disruptions in multiple microbiomes, with the gut microbiota (bacteria, viruses, and fungi) and their metabolites being the most thoroughly researched. This dysbiosis can promote SLE progression through mechanisms such as the leaky gut, molecular mimicry, and epigenetic regulation.SummaryNotwithstanding study constraints on the relationship between microbiota and SLE, specific interventions targeting the gut microbiota, such as probiotics, dietary management, and fecal microbiota transplantation, have emerged as promising SLE therapeutics.
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research