Mild Traumatic Brain Injury-Induced Augmented Postsurgical Pain Is Driven by Central Serotonergic Pain-Facilitatory Signaling

CONCLUSIONS: Collectively, our results show that descending serotoninergic pain-facilitating signaling is responsible for nociceptive sensitization after mTBI and that central endogenous opioid tone opposes serotonin's effects. Understanding brain injury-related changes in endogenous pain modulation may lead to improved pain control for those with TBI undergoing surgery.PMID:37083595 | DOI:10.1213/ANE.0000000000006505

Source: Anesthesia and Analgesia - April 21, 2023 Category: Anesthesiology Authors: QiLiang Chen Peyman Sahbaie Karen-Amanda Irvine J David Clark Source Type: research