Viruses, Vol. 15, Pages 999: Virulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice
Viruses, Vol. 15, Pages 999: Virulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice
Viruses doi: 10.3390/v15040999
Authors:
Yasmin da Silva Santos
Thais Helena Martins Gamon
Marcela Santiago Pacheco de Azevedo
Bruna Larotonda Telezynski
Edmarcia Elisa de Souza
Danielle Bruna Leal de Oliveira
Jamille Gregório Dombrowski
Livia Rosa-Fernandes
Giuseppe Palmisano
Leonardo José de Moura Carvalho
Maria Cecília Rui Luvizotto
Carsten Wrenger
Dimas Tadeu Covas
Rui Curi
Claudio Romero Farias Marinho
Edison Luiz Durigon
Sabrina Epiphanio
Since December 2019, the world has been experiencing the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and we now face the emergence of several variants. We aimed to assess the differences between the wild-type (Wt) (Wuhan) strain and the P.1 (Gamma) and Delta variants using infected K18-hACE2 mice. The clinical manifestations, behavior, virus load, pulmonary capacity, and histopathological alterations were analyzed. The P.1-infected mice showed weight loss and more severe clinical manifestations of COVID-19 than the Wt and Delta-infected mice. The respiratory capacity was reduced in the P.1-infected mice compared to the other groups. Pulmonary histological findings demonstrated that a more aggressive disease was generated by the P.1 and Delta variants compared to the Wt strain of the virus. The quantification of the SARS-Co...
Source: Viruses - Category: Virology Authors: Yasmin da Silva Santos Thais Helena Martins Gamon Marcela Santiago Pacheco de Azevedo Bruna Larotonda Telezynski Edmarcia Elisa de Souza Danielle Bruna Leal de Oliveira Jamille Greg ório Dombrowski Livia Rosa-Fernandes Giuseppe Palmisano Leonardo Jos é Tags: Article Source Type: research
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