Mannosylation is a cause and target in lupus nephritis

Nature Reviews Rheumatology, Published online: 03 April 2023; doi:10.1038/s41584-023-00960-2Autoimmunity-associated recognition by IL-17A-expressing γδ T cells of high-mannose glycans expressed on kidney cells in patients with lupus nephritis can be mitigated in a mouse lupus model by dietary supplementation with N-acetylglucosamine.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research