Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke

CONCLUSIONS: Our research has shown that the disruption of the metal balance plays a crucial role in the pathogenesis of AIS. Furthermore, our results broaden those of previous studies on the exposure to Cd and Pb as risk factors for AIS. Further investigations are necessary to examine the probable mechanisms of Cd and Pb in the onset of ischemic stroke. The Cd/Zn molar ratio may be a useful biomarker of atherosclerosis in AIS patients. An accurate assessment of changes in the molar ratios of essential and toxic trace elements could serve as a valuable indicator of the nutritional status and levels of oxidative stress in AIS patients. It is critical to investigate the potential role of exposure to metal mixtures in AIS, due to its public health implications.PMID:36986164 | DOI:10.3390/nu15061434

Source: Atherosclerosis - March 29, 2023 Category: Cardiology Authors: Anna Miro ńczuk Katarzyna Kapica-Topczewska Katarzyna Socha Jolanta Soroczy ńska Jacek Jamio łkowski Monika Chor ąży Agata Czarnowska Agnieszka Mitrosz Alina Ku łakowska Jan Kochanowicz Source Type: research