Differential expression of plasma microRNA in preeclamptic patients at delivery and 1 year postpartum

Pre-eclampsia (PE) is a hypertensive disorder of pregnancy characterized by widespread maternal endothelial dysfunction. Although clinical signs subside following delivery, long-term risks associated with PE include hypertension, stroke and cardiovascular disease. miRNAs are emerging as critical regulators of biological function, and while alterations to the miRNAome have been described in the context of pregnancy and PE, the postpartum implications of PE on miRNA expression is unknown. The goal of this study was to characterize circulating miRNA profiles at the time of delivery and at one year postpartum for women who did and did not develop PE.

Source: American Journal of Obstetrics and Gynecology - May 13, 2015 Category: OBGYN Authors: Malia S.Q. Murphy, Richard C. Casselman, Chandrakant Tayade, Graeme N. Smith Source Type: research