Idiopathic Pneumonitis Syndrome After Total Body Irradiation in Pediatric Patients Undergoing Myeloablative Hematopoietic Stem Cell Transplantation: A PENTEC Comprehensive Review

Pulmonary complications, especially idiopathic pneumonitis syndrome (IPS), are potentially life altering or fatal sequelae of hematopoietic cell transplantation (HCT). Total body irradiation (TBI) as part of the conditioning regimen has been implicated in IPS. A comprehensive PENTEC (Pediatric Normal Tissues in the Clinic) review was performed to increase our understanding of the role of TBI in the development of acute, noninfectious IPS.

Source: International Journal of Radiation Oncology * Biology * Physics - March 26, 2023 Category: Radiology Authors: Eric D. Ehler, Lucie M. Turcotte, Sonia Skamene, K. Scott Baker, Shiva K. Das, Louis S. Constine, Jianling Yuan, Kathryn E. Dusenbery Tags: CLINICAL INVESTIGATION Source Type: research