Reticulocyte mitochondrial retention increases reactive oxygen species and oxygen consumption in mouse models of sickle cell disease and phlebotomy-induced anemia

Sickle cell disease (SCD) is an inherited blood disorder that affects millions of people worldwide [1,2] and is caused by a point mutation within the β-globin gene, resulting in a substitution of valine for glutamic acid at position 6 in the β-globin chain. The abnormal β-globin chain combines with α-globin resulting in the production of hemoglobin S (HbS). HbS polymerizes on deoxygenation resulting in red cell fragility, hemolysis, and anemi a. In addition, those with SCD suffer from acute and chronic pain episodes, multisystem organ damage, and a shorter lifespan [3].

Source: Experimental Hematology - March 16, 2023 Category: Hematology Authors: Anne Gallivan, Mikail Alejandro, Amarachi Kanu, Nebeyat Zekaryas, Hart Horneman, Lenny K. Hong, Elliott Vinchinsky, Don Lavelle, Alan M. Diamond, Robert E. Molokie, Jagadeesh Ramasamy, Angela Rivers Tags: Article Source Type: research