Acute intermittent porphyria: A rare cause of syndrome of inappropriate antidiuretic hormone secretion

J R Coll Physicians Edinb. 2023 Mar 8:14782715231161499. doi: 10.1177/14782715231161499. Online ahead of print.ABSTRACTA 31-year-old female presented to the emergency department with abdominal pain, vomiting and constipation. Serum sodium levels were recorded at 110 on admission, dropping to 96 despite fluid restriction. The patient developed hallucinations and required hypertonic saline administration in critical care. Urinary sodium was detected at 149, consistent with syndrome of inappropriate antidiuretic hormone secretion (SiADH). Urinary porphyrins were also raised, consistent with a diagnosis of acute intermittent porphyria with SiADH as a complication.PMID:36883342 | DOI:10.1177/14782715231161499

Source: Pain Physician - March 8, 2023 Category: Anesthesiology Authors: William Cunningham Joel Chilaka Nehemiah Edwards Katherine Poulton Source Type: research