The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease < em > via < /em > regulating PI3K/AKT, ERK and PPAR γ signaling pathways

In this study, we found that QBF or Los treatment could decrease serum BUN, CRE, UA levels and reduce urine albumin-to-creatinine ratio (ACR) in DKD rats. Additionally, QBF or Los treatment obviously inhibited glomerular mesangial expansion and glomerular fibrosis, attenuated glomerular injury in kidney tissues of DKD rats. Moreover, QBF or Los treatment significantly reduced PI3K, AKT and ERK1/2 protein expressions, but increased PPAR γ level in kidney tissues of DKD rats. As expected, combined treatment of QBF and Los could exert enhanced reno-protective effects compared with the single treatment. Collectively, combination of QBF and Los could ameliorate renal injury and fibrosis in DKD ratsvia regulating PI3K/AKT, ERK and PPAR γ signaling pathways. These findings highlight the therapeutic potential of QBF to prevent DKD progression.
Source: European Journal of Histochemistry - Category: Biomedical Science Authors: Source Type: research