Fibroblastic growth factor 23 linking iron and bone metabolism. Hypothesis on how FGF23 is effected by blood donation

Fibroblastic growth factor 23 (FGF23) is a circulating hormone mainly secreted by the osteocytes in the bone. Around 2000, after decades of research, FGF23 was discovered as being the “circulating factor phosphatonin” that causes the symptoms in patients with autosomal dominant hypophosphatemic rickets (ADHR). This disease is characterized by hypophosphatemia and hypophosphaturia resulting in growth retardation, bone deformities and rickets. Patients with ADHR develop flares of hypophosphatemia that coincidence with the development of iron deficiency and thus microcytic anemia [1,2].
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Tags: Review Source Type: research