Design and construction of Carboxylesterase 2c Gene knockout Rats by CRISPR/Cas9

CONCLUSION: The Ces2c KO rat model was successfully constructed by CRISPR/Cas9 system. This rat model can not only be used as an important tool to study the drug metabolism mediated by Ces2, but also as an important animal model to study the physiological function of Ces2.PMID:36694315 | DOI:10.2174/1389200224666230123140919

Source: Current Drug Metabolism - January 25, 2023 Category: Drugs & Pharmacology Authors: Jie Liu Xuyang Shang Bingyi Yao Yuanjin Zhang Shengbo Huang Yuanqing Guo Xin Wang Source Type: research