Anti-malaria drug artesunate prevents development of amyloid- β pathology in mice by upregulating PICALM at the blood-brain barrier

PICALM is one of the most significant susceptibility factors for Alzheimer ’s disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. ...

Source: Molecular Neurodegeneration - January 27, 2023 Category: Neurology Authors: Kassandra Kisler, Abhay P. Sagare, Divna Lazic, Sam Bazzi, Erica Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao and Berislav V. Zlokovic Tags: Research article Source Type: research