Selective CD28 blockade impacts T cell differentiation during homeostatic reconstitution following lymphodepletion

DiscussionThese data demonstrate that CD28 signaling impacts the differentiation of both CD4+ and CD8+ T cells during homeostatic reconstitution following lymphodepletion, resulting in a shift towards fewer activated memory T cells and more CD8+FoxP3+ T cells, a profile that may underpin the observed prolongation in allograft survival.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research