Selinexor –Bortezomib–Dexamethasone: A Review in Previously Treated Multiple Myeloma

AbstractSelinexor [Nexpovio® (EU); Xpovio® (USA)] is a first-in-class, selective exportin-1 inhibitor. Oral selinexor once weekly in combination with subcutaneous bortezomib once weekly and oral dexamethasone twice weekly (selinexor –bortezomib–dexamethasone) is approved in the EU and USA for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. In the open-label, randomized, phase 3 BOSTON trial, this regimen significantly prolonged progression-free survival (PFS) compared with the standard bortezomib–dexamethasone regimen in patients with previously treated multiple myeloma. Selinexor–bortezomib–dexamethasone had a generally manageable tolerability profile and an acceptable safety profile in BOSTON, with a lower incidence of peripheral neuropathy (a bortezomib-indu ced toxicity) compared with bortezomib–dexamethasone. The triplet regimen uses less bortezomib and dexamethasone during the first 24 weeks of treatment. The efficacy and safety profiles of selinexor–bortezomib–dexamethasone, combined with its once-weekly administration of selinexor and bortezo mib, make it a useful additional triplet therapy option for previously treated multiple myeloma.

Source: Targeted Oncology - January 9, 2023 Category: Cancer & Oncology Source Type: research