Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance

ConclusionsTherapeutically targeting estrogen receptors may have a limiting effect on eosinophils, ILC2 and potentially other immune populations that may improve asthma symptoms in those females that experience perimenstrual worsening of asthma, with the caveat, that long-term use of estrogens or hormone receptor modulators may be detrimental to the lung microenvironment over time.
Source: Biology of Sex Differences - Category: Biology Source Type: research