Correlation Between Estrogen Receptor α Gene Polymorphism (c454-397T & gt;C) with Serum Estradiol Levels and Known Risk Factors in Patients with Myocardial Infarction

AbstractMyocardial infarction (MI) remains the most common cause of cardiac failure and continuous increasing rate of morbidity and mortality. We aimed to investigate the  association of estrogen receptor-α (ESR1) gene polymorphism c454-397T>C with serum estradiol levels and dyslipidemia in 220 patients with MI in the age range of 35 –70 years of both the genders. Genotyping study was performed through PCR-RFLP method using PvuII restriction enzyme. Serum estradiol level was estimated using the Access Sensitive Estradiol assay kit. Men patients had 43.2% increased risk for TC heterozygote in co-dominant (OR 10.66) and over-do minant models (OR 8.30), while women patients had 50% increased risk in co-dominant (OR 16.57) and over-dominant (OR 14.04) models. Variant C allele showed 25% increased risk of MI for in men (OR 2.24; CI 1.49–3.36;p = 0.0001), and 24% increased risk in women (OR 3.35; CI 1.95–5.76;p = 0.0001). Men patients had significantly increased serum estradiol levels compared to controls (25.28 ± 5.80 vs 17.04 ± 2.01;p <  0.0001). Significant difference was observed in estradiol levels between men and women patients (25.28 ± 5.80 vs 17.56 ± 3.32;p <  0.0001). Furthermore, significantly increased estradiol level was found in men patients compared to women for TT (25.46 ± 5.91 vs 16.71 ± 4.46;p <  0.0001), and TC genotypes (25.47 ± 5.91 vs 17.70 ± 2.86;p <  0.0001). Significantly...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research