Enhanced delivery of a low dose of aducanumab via FUS in 5 ×FAD mice, an AD model

ConclusionIn conclusion, the enhanced delivery of a low dose of Adu (3 mg/kg) via FUS decreases amyloid deposits and attenuates cognitive function deficits. FUS-mediated BBB opening increases adult hippocampal neurogenesis as well as drug delivery. We present an AD treatment strategy through the synergistic effect of the combined therapy of FUS and Adu.

http://link.springer.com/10.1186/s40035-022-00333-x

Source: Translational Neurodegeneration - December 27, 2022 Category: Neurology Source Type: research