Cold stress ‐induced bladder overactivity in type 2 diabetic mellitus rats is mitigated by the combination of a M3‐muscarinic antagonist and a β3‐adrenergic agonist

ConclusionsThe cold stress-induced bladder overactivity was not improved by either the M3-muscarinic receptor antagonist or the β3-adrenergic receptor agonist alone. However, the combined treatment mitigated the cold stress responses. Combined therapy with M3-muscarinic antagonists and β3-adrenergic agonists could reduce side effects and improve the quality of life for diabetic patients with bladder overactivity.

Source: LUTS: Lower Urinary Tract Symptoms - December 22, 2022 Category: Urology & Nephrology Authors: Hiroaki Hara, Tetsuya Imamura, Ataru Suzuki, Manabu Ueno, Tomonori Minagawa, Teruyuki Ogawa, Osamu Ishizuka Tags: ORIGINAL ARTICLE Source Type: research