Brain pharmacokinetics of mono- and bispecific amyloid- β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

ConclusionThe BBB-penetrating bispecific antibody displayed higher ISF concentrations than the monospecific antibody. The concentration difference between the two antibodies was even larger in the whole brain than in the ISF. Further, the bispecific antibody, but not the monospecific antibody, displayed higher total brain concentrations than ISF concentrations, indicating association to brain tissue.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research