The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates

This study recruited ASPD and non-ASPD male subjects who had committed violent crimes from a prison in Nanjing, China. By comparing the two groups' genotypes, allele frequencies, and histories of childhood abuse, we explored the interaction between the NOS1AP gene and childhood maltreatment on the pathogenesis of ASPD. The results showed that polymorphism rs945713 in the NOS1AP gene was associated with ASPD and furthermore that this SNP may be involved in regulating the effect of childhood abuse on ASPD. This study found that childhood trauma increases the risk of ASPD in violent adult male inmates; for prisoners with ASPD, it is critical to pay attention to their childhood trauma and take early psychological intervention.

Source: Personality and Mental Health - December 5, 2022 Category: Psychiatry Authors: Jinyang Li, Lichen Ouyang, Xinyao Liu, Qiuyu Wang, Zhang Min, Gang Liu, Yuan Zhong, Ning Zhang, Chun Wang, Na Liu Tags: RESEARCH ARTICLE Source Type: research