Hemodynamic performance of INSPIRIS RESILIA aortic bioprosthesis for severe aortic stenosis: 2-year follow-up in Japanese cohort

AbstractThe INSPIRIS RESILIA aortic bioprosthesis (Edwards Lifesciences LLC, Irvine, USA) was fixed in novel tissue preservation technology to ensure long-term durability. Hemodynamic performance after aortic valve replacement (AVR) for severe aortic stenosis (AS) has not been published in the Japanese cohort. Twenty-nine patients underwent AVR with INSPIRIS RESILIA bioprosthesis for severe AS between November 1, 2018 and December 31, 2020. The mean age was 75.1  ± 4.5 years with 19 female patients. Body surface area was 1.58 ± 0.19 m2 and New York Heart Association functional class was 2.2  ± 0.5. Hemodynamic performance was assessed using follow-up transthoracic echocardiographic data collected at 3–6 months, 1 year and 2 years. The mean follow-up time was 19.2 ± 7.2 months, with a 100% follow-up rate. One patient died of postoperative heart failure. The preoperative mean and peak transvalvular pressure gradients (PGs) were 51.9 ± 18.4 mmHg and 89.3 ± 34.9 mmHg, respectively, and effective orifice area 0.72 ± 0.26 cm2. They improved at 10.2  ± 3.5 mmHg (p <  0.0001), 19.3 ± 6.6 mmHg (p <  0.0001) and 1.73 ± 0.47cm2 (p <  0.0001) at discharge. The mean transvalvular PG at 3–6 months (n = 24), 1 year (n = 25) and 2 years (n = 15) was 11.2 ± 3.8 mmHg (p <  0.0001), 11.1 ± 3.2 mmHg (p <  0.0001) and 11.2 ± 3.3 mmHg (p <  0.0001), respectively...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research