A novel chronic guinea pig model of COPD using LPS and poly(I:C) exposure

Conclusion: A novel chronic model of COPD was implemented using 12 weeks, twice weekly exposure to LPS and poly(I:C). The model is characterized by airway fibrosis, septal thickening and possibly right ventricle hypertrophy. The effect on inflammation was reversed by tiotropium in the validation study.

Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: De Looff, M., Verschut, V., Woest, M. E., Gorter, I. C., Belfor, K. S., Bos, I. S. T., De Jager, M. H., Gosens, R., Villetti, G., Facchinetti, F., Kistemaker, L. E. M. Tags: 05.01 - Airway pharmacology and treatment Source Type: research