3. Homologous Recombination DNA Repair Deficiency in Hematological Malignancies

Genomic instability due to homologous recombination repair deficiency (HRD) predicts adverse prognosis in ovarian/ breast cancer with favorable responses to PARP inhibitors. HRD is a measure of genomic scar (GS) signatures associated with loss-of-heterozygosity (LOH), telomeric allelic imbalance (TAI), and large-scale state transitions (LST), excluding aneuploidy. While aneuploidy is a known poor prognostic marker in hematological malignancies (HM), the significance of HRD has not been explored.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Ha Nguyen, Sherin Raju, Nazneen Ahmed, Diana Rush, Mark Dubina, Hector Alvarez, Anthony San Lucas, Zhenya Tang, Bedia Barkoh, Hyvan Dang, James Ozenci, Simi Puthooran, Peter Hu, Awdhesh Kalia, Christopher Bowman, Luthra Rajyalakshmi, Rashmi Kanagal-Shaman Source Type: research