Reduced IFN- γ along with Changes in Hematological and Immunological parameters are Key to COVID-19 Severity in Bangladeshi Patients

The COVID-19 pandemic engendered by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has had a global disaster since its outbreak in Wuhan, China in December 2019 [1]. As of March 2022, there were over 507 million confirmed COVID-19 cases and a death toll of more than 62 million with a case-fatality rate ranging from 0 ∙04%-18∙18% reported worldwide whereas Bangladesh has experienced approximately 2 million cases and total death of less than 30000 [2]. The disparity of the mortality rates caused by COVID-19 in different regions of the world has been a puzzling conundrum but grossly alluded to demographic varia bles such as age and gender, ethnicity, presence or absence of comorbidities, HLA genotype, genetically inherited immunity, acquired immunity by exposure to a wide variety of pathogens, and a lifestyle reinforcing immunity [3, 4].

Source: Experimental Hematology - November 26, 2022 Category: Hematology Authors: Mohammed Moinul Islam, Shafiqul Islam, Ridwan Ahmed, Mohit Majumder, Bishu Sarkar, Md. Ejajur Rahman Himu, Md Kawser, Alamgir Hossain, Mohammad Jewel Mia, Rashed Rezwan Parag, Md. Rakibul Hassan Bulbul, Shakeel Ahmed, M.A. Sattar, Rajdeep Biswas, Moumita Tags: Article Source Type: research