Bone scintigraphy in suspected HCM – Cardiology MCQ

Bone scintigraphy with 99mTc-DPD is useful in hypertrophic cardiomyopathy (HCM) to exclude:
a) HCM due to sarcomere protein mutations
b) Fabry disease
c) Danon disease
d) TTR amyloidosis
Correct answer: d) TTR amyloidosis
Transthyretin (TTR), the precursor protein in senile systemic amyloidosis and familial TTR-related amyloidosis is a tetrameric plasma transport protein synthesized in the liver.  TTR-derived fibrils show avidity for bone tracers, especially 99mTechnetium-3,3-diphosphono-1,2-propano-di-carboxylic acid
(99mTc-DPD).

Source: Cardiophile MD - April 29, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs