The Possible Protective Effects of Ondansetron and Tropisetron on Optic Nerve Crush Injury in Rats

Conclusion Our findings indicate that cyclosporine, ondansetron, and
tropisetron protect against ONC injury in rats, possibly via the suppression of
apoptosis and modulation of calcineurin activity directly and via 5-HT3
receptors. Moreover, immunoblotting showed that tropisetron was more effective
as opposed to ondansetron. Further studies are needed to evaluate the precise
mechanism behind cyclosporine, ondansetron, and tropisetron activities. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Drug Research - November 24, 2022 Category: Drugs & Pharmacology Authors: Shayan, Maryam Eslami, Faezeh Khosravi, Ayda Rashidian, Amir Jafari, Razie Mohammad Maroufi, Seyed Farzad Golroudbari, Hasti Tashak Dehpour, Ahmad Reza Tags: Original Article Source Type: research