Novel hybrid total artificial heart with integrated oxygenator
In this study, we investigated the design and improvement of the blood flow pathway from the inflow-to-outflow of four oxygenators using a mathematical model and computational fluid dynamics (CFD). Pressure loss and gas transport through diffusion were examined to assess oxygenator design. The oxygenator designs led to a resistance-driven pressure loss range of less than 35 mmHg for flow rates of 1–7 L/min. All of the designs met requirements. The configuration having an outside-to-inside blood flow direction was found to have higher oxygen transport. Based on this advantageous flow direction, two designs (Model 1 and 3) were then integrated with the axial-flow impeller of the TAH for simulation. Flow rates of 1–7 L/min and speeds of 10,000–16,000 RPM were analyzed. Blood damage studies were performed, and Model 1 demonstrated the lowest potential for hemolysis. Future work will focus on developing and testing a physical prototype for integration int o the new cardiopulmonary assist system.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Steven G. Chopski,
Krianthan Govender,
Alexandra May,
Ellen Garven,
Randy M. Stevens,
Vakhtang Tchantchaleishvili,
Amy L. Throckmorton Tags: ORIGINAL ARTICLE Source Type: research
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