A Novel and Reversible Experimental Primate Ocular Hypertension Model: Blocking Schlemm ’s Canal

Introduction: The purpose of this study was to establish a novel and reversible experimental ocular hypertension primate model by blocking Schlemm ’s canal. Methods: A model was induced in adult cynomolgus monkeys (n=4) by blocking Schlemm’s canal with an inserted microcatheter (200 μm diameter); it was removed 6 weeks later from one monkey to reverse the elevated intraocular hypertension. All animals were monitored for 11 months; weekly measurements of intraocular pressure and biweekly examinations with spectral domain optical coherence tomography and disc photography were performed. Histopathology of the eye and retinal ganglion cell counts were completed at the end of the study. Results: The intraocular pressure of the blocked eyes was significantly higher than that of the contralateral eyes at 1 month after the blockage (P
Source: Ophthalmic Research - Category: Opthalmology Source Type: research