Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation

Conditions:   Locally Advanced Rectal Carcinoma;   Stage II Rectal Cancer AJCC v8;   Stage III Rectal Cancer AJCC v8 Interventions:   Drug: Capecitabine;   Drug: 5-fluorouracil;   Drug: Leucovorin calcium;   Drug: Irinotecan;   Drug: Oxaliplatin;   Radiation: Long Course Chemoradiotherapy;   Procedure: Computed Tomography;   Procedure: Magnetic Resonance Imaging;   Procedure: Sigmoidoscopy;   Procedure:  biopsy Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials