Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation
Conditions: Locally Advanced Rectal Carcinoma; Stage II Rectal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8 Interventions: Drug: Capecitabine; Drug: 5-fluorouracil; Drug: Leucovorin calcium; Drug: Irinotecan; Drug: Oxaliplatin; Radiation: Long Course Chemoradiotherapy; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Procedure: Sigmoidoscopy; Procedure: biopsy Sponsors: Alliance for Clinical Trials in Oncology; National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Calcium | Cancer | Cancer & Oncology | Carcinoma | Chemotherapy | Eloxatin | Radiation Therapy | Rectal Cancers | Research | Sigmoidoscopy | Xeloda