Small round blue cell sarcomas of bone: an update on classification, pathology and molecular profiling

Small round cell sarcomas of bone are extremely aggressive tumors, most often occurring in children and young adults. Recent genomic discoveries have contributed to the current classification of these tumors. The latest edition of the WHO Classification of Tumors of Soft Tissue and Bone identifies four subcategories each with distinct clinical features and prognostic outcome- Ewing sarcoma with ETS rearrangements and tumors with gene fusions involving EWSR1-non-ETS, CIC -rearranged tumors and sarcoma with BCOR genetic alterations.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: bone pathology Source Type: research