The hsa-miR-516a-5p and hsa-miR-516b-5p microRNAs reduce the migration and invasion on T98G glioblastoma cell line.

Glioblastoma multiforme (GBM) is a type of cancer that affects the glial cells in the brain or spinal cord at a very low rate. This type of malignity is aggressive and lethal with a median overall survival (OS) of approximately 10 to 20  months [1–3]. The aggressiveness of GBM is given possibly by high epigenetic and genetic variability observed in tumor cells, which can trigger a high metastatic potential in other parts of the brain, complicating the efficacy of therapies such as surgery, radiotherapy, chemotherapy, among othe r [1, 4–6].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research