Molecules, Vol. 27, Pages 7487: Antihypothyroid Effect of Salidroside
Molecules, Vol. 27, Pages 7487: Antihypothyroid Effect of Salidroside
Molecules doi: 10.3390/molecules27217487
Authors:
Nazym K. Korbozova
Nataliya O. Kudrina
Nataliya A. Zhukova
Alexander E. Grazhdannikov
Irina V. Blavachinskaya
Gulnaz A. Seitimova
Timur E. Kulmanov
Tatyana G. Tolstikova
Nina V. Terletskaya
In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of Rhodiola spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from R. semenovii roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (p ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of R. semenovii extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times.
Source: Molecules - Category: Chemistry Authors: Nazym K. Korbozova Nataliya O. Kudrina Nataliya A. Zhukova Alexander E. Grazhdannikov Irina V. Blavachinskaya Gulnaz A. Seitimova Timur E. Kulmanov Tatyana G. Tolstikova Nina V. Terletskaya Tags: Article Source Type: research
More News: Chemistry | Complementary Medicine | Endocrinology | Herbs | Hormones | Hypothyroidism | Pathology | Potassium | Rhodiola | Study | Thyroid | Toxicology