Effect of aging on immune cells in male HIV-infected and -uninfected healthy individuals

Objective: HIV induces immunologic dysfunction in T cells of infected individuals. However, the impact of aging on T cell phenotypes in HIV-infected individuals receiving antiretroviral therapy (ART) has not been fully delineated. We evaluated the relationship between aging and the expression of immune activation and exhaustion markers on CD8+ T cells of age-matched HIV-infected and -uninfected male participants. Design: Levels of immune activation and exhaustion markers on peripheral blood CD8+ T cells of HIV-infected and -uninfected participants were examined. Methods: 110 HIV-infected aviremic male participants receiving ART and 146 HIV-uninfected male participants were studied. The levels of TIGIT, PD-1, CD38, and CD226 on CD8+ T cells of the study participants were determined by flow cytometry. Results: The level of TIGIT on CD8+ T cells was higher in aviremic HIV-infected compared to uninfected participants (P 
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research