Sleep architecture in progressive supranuclear palsy: A video-polysomnography study

Conclusions: Sleep architecture is altered in PSP even during the early stages of the disease. There is reduced total sleep including both non-REM and REM sleep, sleep efficiency, prolonged sleep latencies, and increased wake duration. This correlates with the neurodegenerative processes affecting the anatomical region regulating the sleep/wake cycle like dorsal raphe nucleus, locus coeruleus (LC), pedunculopontine nucleus (PPN).
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research