K index utility as diagnostic and prognostic biomarker in the assessment of patients with suspected Multiple Sclerosis

The aim of the present study is to evaluate the composite role of k index in the initial assessment of Multiple Sclerosis (MS) patients and to select useful cut-offs exportable in clinical practice. We analysed CSF/serum samples of 140 patients and followed-up the CIS/MS subgroup for 7  years. Our results suggest κ index as a quantitative diagnostic and prognostic biomarker in MS, significantly associated to baseline lesion load and to successive clinical course. We propose k index ≥106 as a prognostic cut-off to select patients at major risk of relapse, potentially influenci ng initial therapeutic decisions.

Source: Journal of Neuroimmunology - October 27, 2022 Category: Allergy & Immunology Authors: Claudia Cutell è, Claudia Balducci, Diletta Cereda, Maria Letizia Fusco, Davide Iacobucci, Jacopo Perugini, Fiammetta Pirro, Rinaldo Brivio, Davide Paolo Bernasconi, Carlo Ferrarese, Maura Frigo, Guido Cavaletti Source Type: research