The Role of the Non-Steroidal Mineralocorticoid Antagonist Finerenone in Cardiorenal Management

This article provides an overview of recent evidence of benefits on cardiovascular (CV) outcomes.Recent FindingsThe recently published phase III FIDELIO-DKD and FIGARO-DKD, alone and pooled, in patients with CKD and diabetes demonstrate that finerenone reduces the composite of CV death, non-fatal myocardial infarction, nonfatal stroke, and hospitalization for heart failure (HF) with hospitalization for HF being the primary driver of this composite.SummaryFinerenone is indicated to reduce renal and CV outcomes in patients with CKD and diabetes. Future investigations of this agent include patients with non-diabetic CKD, HF with preserved ejection fraction, and with the use of sodium-glucose transporter type 2 inhibitors.
Source: Current Cardiology Reports - Category: Cardiology Source Type: research